Hemodialysis is used in patients with kidney failure to remove waste products such as urea from the blood. A high urea level means that the levels of other waste products, likely more harmful and not as easily measured, are also building up. To see whether dialysis is removing enough urea (dialysis adequacy), a time consuming process of sampling blood intermittently to measure the urea reduction ratio (URR) or Kt/V value is used.
With the advent of UVC LEDs, spectroscopy in real-time can be a non-invasive method to determine the reduction in the concentration of urinary excreted substances in the dialysate drain. Ultraviolet light at 280 nm is absorbed by urea molecules present in the spent dialysate which is correlated to their concentration in the blood. Real-time monitoring during the entire treatment period helps healthcare professionals provide their patients an optimal dialysis dose and allows them to adjust treatment parameters for the benefit of patients.
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